It borders the districts of Iganga in the East, Jinja in the south, Kayunga in the west, Soroti in the north and Pallisa in the north-east. In 1974, the provincial Administration Kamuli was part of North Busoga province. North Busoga Province became Kamuli District in 1980. At Independence, Busoga District comprised of the present day Bugiri, Iganga, Kamuli, Jinja and Mayuge Districts. The main language spoken is Lusoga.
The district has over 712,079 people, 365,232 of which are female and 346,847 are male.
There Agriculture with main emphasis on food crops such as millet, potatoes, beans, Simsim and sunflower. Cash crops like cotton, coffee and Sugar cane. There fruits and vegetables like Tomatoes, vegetables and Onions.
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The district has a total of 327 primary schools with 301 government, 14 private and 12 community schools. For secondary schools, the district has over 56 schools, 15 are government, 23 private and 18 community.
The district has 8 Government dispensaries (II), 17 health centres (III) at county, 5 health centres (IV) at sub-district with no hospital. More so, it has 23 private/NGO dispensaries, 13 clinics and no health centre (III) and hospital. There is also Kamuli Mission Hospital with 153 beds.